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| Nomenclature |
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Symbol:
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Lphn1tm1Sud
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Name:
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latrophilin 1;
targeted mutation 1, Thomas C Sudhof
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MGI ID: |
MGI:3691022 |
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Gene:
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Lphn1
Location:
Chr8:83900105-83941954 bp, + strand
Genetic Position: Chr8,
40.22 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:115214
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 2, which encodes amino acids 24-95, and some flanking intronic DNA have been replaced by a neomycin resistance cassette, generating a translational reading-frame shift. Immunoblot analysis with antibodies against the N-terminal, extracellular part of the protein demonstrated its absence in synoptosomes of homozygous mutant mice. (J:115214)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:115214
Tobaben S et al.,
"Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha."
J Biol Chem 2002 Feb 22;277(8):6359-65
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All: |
1 reference(s)
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Analysis Tools
