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| Nomenclature |
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Symbol:
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Tg(tetO-EGFR*L858R)56Hev
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Name:
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transgene insertion 56, Harold E Varmus
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MGI ID: |
MGI:3690078 |
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Synonyms: |
EGFRL858R, L858R56, TetO-EGFRL858R |
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Transgene:
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Tg(tetO-EGFR*L858R)56Hev
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A mutant human epidermal growth factor receptor (EGFR) cDNA with a T-to-G nucleotide substitution in exon 21 that replaces leucine with arginine at amino acid position 858 (L858R) was cloned between a tetracycline-responsive element and an intron and polyadenylation signal from the mouse protamine 1 gene. Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) protein under control of a tissue- specific promoter can be induced to express the mutant EGFR in tissues or cell types of interest by administration/withdrawal of doxycycline. (J:109092)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Line 57 was also generated.
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| References |
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Original: |
J:109092
Politi K et al.,
"Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors."
Genes Dev 2006 Jun 1;20(11):1496-510
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All: |
4 reference(s)
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Analysis Tools
