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| Nomenclature |
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Symbol:
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Mogtm1(cre)Gkl
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Name:
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myelin oligodendrocyte glycoprotein;
targeted mutation 1, George Kollias
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MGI ID: |
MGI:3689957 |
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Synonyms: |
MOGi-cre |
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Gene:
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Mog
Location:
Chr17:37010746-37023398 bp, - strand
Genetic Position: Chr17,
19.16 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:114741
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Parent Cell Line:
| Bruce 4 (ES Cell) |
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Strain of Origin:
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B6.Cg-Thy1a
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The open reading frame of the Cre recombinase gene, followed by the human growth hormone polyadenylation signal and the neomycin resistance gene, has replaced all except the 5'-most segment of the first exon, the first intron and all but the 3'-most part of the second exon of the myelin oligodendrocyte glycoprotein gene, thus targeting Cre expression to oligodendrocytes (ODCs). Western blot analysis demonstrated that wild-type MOG protein is present in heterozygous and wild-type brains at comparable levels, but is not detectable in homozygous mutant brain. (J:114741)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mog Mutation:
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37 strains or lines available |
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| References |
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Original: |
J:114741
Hovelmeyer N et al.,
"Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis."
J Immunol 2005 Nov 1;175(9):5875-84
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All: |
5 reference(s)
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Analysis Tools
