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| Nomenclature |
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Symbol:
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Tg(Sp7-tTA,tetO-EGFP/cre)1Amc
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Name:
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transgene insertion 1, Andrew P McMahon
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MGI ID: |
MGI:3689350 |
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Synonyms: |
osterix-Cre, Osx1-cre, Osx1-GFP::Cre, Osx-Cre, Osx-Cre::GFP |
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Transgene:
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Tg(Sp7-tTA,tetO-EGFP/cre)1Amc
Location:
unknown
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Show the 2 image(s) involving this allele.
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: A tTA-regulated GFP::Cre construct, which has the tetracycline-regulated transactivator (tTA) cassette upstream of a tetracycline-responsive element (tetO)-controlled Enhanced Green Fluorescent Protein/cre fusion protein was used to modifiy a bacterial artificial chromosome (BAC) encoding exon 1 of the mouse Sp7 gene (formerly osterix or Osx1). A frt-flanked selection cassette following the tTA-regulated GFP::Cre was removed from correctly targeted bacteria via transient flpe expression.
A 5.2 kb portion of the modified BAC (Osx1-GFP::Cre) was used for pronuclear injection into fertilized CD1 embryos. (J:114494)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:114494
Rodda SJ et al.,
"Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors."
Development 2006 Aug;133(16):3231-44
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All: |
37 reference(s)
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Analysis Tools
