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| Nomenclature |
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Symbol:
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Apctm2Rak
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Name:
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adenomatosis polyposis coli;
targeted mutation 2, Raju Kucherlapati
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MGI ID: |
MGI:3688435 |
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Synonyms: |
Apc580S, ApcCKO |
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Gene:
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Apc
Location:
Chr18:34220924-34318608 bp, + strand
Genetic Position: Chr18,
18.53 cM
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Stunted growth, short whiskers, sparse hair coat and abnormal tooth development in the Apctm2Rak/Apctm2Rak Tg(KRT14-cre)8Brn/0 mouse
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:114152
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Parent Cell Line:
| WW6 (ES Cell) |
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Strain of Origin:
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STOCK 129/Sv and C57BL/6J and SJL
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites were inserted through homologous recombination to flank exon 14. An adjacently inserted frt-flanked neomycin selection cassette was removed through Flp-mediated recombination, leaving a single frt site in intron 14. (J:114152)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Apc Mutation:
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50 strains or lines available |
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| References |
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Original: |
J:114152
Kuraguchi M et al.,
"Adenomatous Polyposis Coli (APC) is required for normal development of skin and thymus"
PLoS Genet 2006;2(9):e146
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All: |
8 reference(s)
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Analysis Tools
