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| Nomenclature |
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Symbol:
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Cftrtm3Mrc
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Name:
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cystic fibrosis transmembrane conductance regulator;
targeted mutation 3, Mario R Capecchi
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MGI ID: |
MGI:3688292 |
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Synonyms: |
Cftrtm3Uth, Y122X |
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Gene:
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Cftr
Location:
Chr6:18170687-18322768 bp, + strand
Genetic Position: Chr6,
8.1 cM, cytoband A3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:112450
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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These mice contain the Y122X mutation. (J:112450)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cftr Mutation:
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13 strains or lines available |
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| References |
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Original: |
J:112450
van Heeckeren AM et al.,
"Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice."
Am J Physiol Lung Cell Mol Physiol 2004 Nov;287(5):L944-52
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All: |
1 reference(s)
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Analysis Tools
