|
|
| Nomenclature |
|
Symbol:
|
Igktm1(Igk564)Tik
|
|
Name:
|
immunoglobulin kappa chain complex;
targeted mutation 1, Thereza Imanishi-Kari
|
|
MGI ID: |
MGI:3687307 |
|
Gene:
|
Igk
Location:
unknown
Genetic Position: Chr6,
30.89 cM, cytoband F1-pter
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:113555
|
|
Parent Cell Line:
| J1 (ES Cell) |
|
Strain of Origin:
|
129S4/SvJae
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutations: | |
Insertion, Intergenic deletion |
| |
|
Mutation details: A floxed neomycine resistance gene, as well as the 564 VkappaJkappa5 region from a hybridoma derived from an autoimmune SWRxNZB mouse, replaced a segment of DNA including the entire J kappa region. Male chimeric mice were bred to C57BL/6 females. Offspring from these mice were crossed with cre expressing transgenic mice in order to excise the neomycin resistance cassette. (J:113555)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Igk Mutation:
|
15 strains or lines available |
|
| References |
|
Original: |
J:113555
Berland R et al.,
"Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice."
Immunity 2006 Sep;25(3):429-40
|
|
All: |
1 reference(s)
|
|
Analysis Tools
