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| Nomenclature |
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Symbol:
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Ightm1(Igh564)Tik
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Name:
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immunoglobulin heavy chain complex;
targeted mutation 1, Thereza Imanishi-Kari
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MGI ID: |
MGI:3687305 |
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Synonyms: |
IgH564 |
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Gene:
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Igh
Location:
unknown
Genetic Position: Chr12,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:113555
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A floxed neomycine resistance gene, as well as the VDJ 564 region from a hybridoma derived from an autoimmune SWRxNZB mouse, replaced a segment of DNA including DQ52 and the entire JH region. Male chimeric mice were bred to C57BL/6 females. The resulting offspring were crossed with cre expressing transgenic mice in order to excise the neomycin resistance cassette. (personal communication)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Igh Mutation:
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25 strains or lines available |
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| References |
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Original: |
J:113555
Berland R et al.,
"Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice."
Immunity 2006 Sep;25(3):429-40
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All: |
1 reference(s)
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Analysis Tools
