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| Nomenclature |
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Symbol:
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Tg(Col2a1-cre/ERT)KA3Smac
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Name:
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transgene insertion KA3, Susan Mackem
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MGI ID: |
MGI:3665440 |
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Synonyms: |
Col2CreERT, Tg(Col2a1-cre/ESR1)1Smac, Tg(Col2a1-cre/ESR1)KA3Smac |
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Transgene:
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Tg(Col2a1-cre/ERT)KA3Smac
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: This transgene expresses a tamoxifen inducible form of cre recombinase driven by the Col2a1 promoter in cartilage. The cre recombinase coding region is joined to sequence encoding the ligand binding domain of the human estrogen receptor with a glycine to arginine missense mutation at position 521. This substitution enables the domain to bind to tamoxifen while ablating the estradiol binding ability. (J:35420, J:111627)
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Recombinase activity
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Activity in:
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embryo-other,
head,
limbs,
mesenchyme,
postnatal-other,
respiratory system,
skeletal system,
tail
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Not detected in:
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cardiovascular system,
integumental system,
liver & biliary system,
nervous system,
renal & urinary system,
reproductive system,
sensory organs
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Driver:
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Col2a1
Summary of all recombinase alleles
driven by Col2a1.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:111627
Nakamura E et al.,
"Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton."
Dev Dyn 2006 Aug 7;235(9):2603-2612
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All: |
17 reference(s)
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Analysis Tools
