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| Nomenclature |
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Symbol:
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Ercc2tm3Jhjh
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Name:
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excision repair cross-complementing rodent repair deficiency, complementation group 2;
targeted mutation 3, Jan H J Hoeijmakers
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MGI ID: |
MGI:3664604 |
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Synonyms: |
XpdG602D, XpdXPCS |
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Gene:
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Ercc2
Location:
Chr7:19382010-19395694 bp, + strand
Genetic Position: Chr7,
9.62 cM
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Microglia activation in the white matter in Ercc2, Ercc6, and Ercc8 mutants
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:112689
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: A G602D point mutation was inserted with a loxP-flanked neo in the 3' UTR. The neo was subsequently removed via cre-mediated recombination. RT-PCR detected comparable expression between mutants and wild-types. (J:112689)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ercc2 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:112689
Andressoo JO et al.,
"An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria."
Cancer Cell 2006 Aug;10(2):121-32
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All: |
5 reference(s)
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Analysis Tools
