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| Nomenclature |
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Symbol:
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Ncoa1tm1.1Hkaw
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Name:
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nuclear receptor coactivator 1;
targeted mutation 1.1, Hiroshi Kawaguchi
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MGI ID: |
MGI:3664107 |
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Synonyms: |
SRC-1- |
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Gene:
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Ncoa1
Location:
Chr12:4247363-4477182 bp, - strand
Genetic Position: Chr12,
2.05 cM, cytoband A2-A3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:111490
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Cre-mediated deletion of exon 4 resulted in the creation of a stop codon at exon 5 by splicing exon 3 and 5 transcripts. The truncated protein resulting from this allele lacks the C-terminal region. (J:111490)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:111490
Yamada T et al.,
"SRC-1 is necessary for skeletal responses to sex hormones in both males and females."
J Bone Miner Res 2004 Sep;19(9):1452-61
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All: |
1 reference(s)
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Analysis Tools
