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| Nomenclature |
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Symbol:
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Scnn1gtm1Bhk
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Name:
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sodium channel, nonvoltage-gated 1 gamma;
targeted mutation 1, Beverly H Koller
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MGI ID: |
MGI:3663382 |
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Synonyms: |
gammaENaC- |
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Gene:
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Scnn1g
Location:
Chr7:121734479-121768475 bp, + strand
Genetic Position: Chr7,
65.07 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50528
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced the exon with the putative start codon. Northern blot analysis on RNA derived from kidney demonstrated that no detectable protein is expressed from this allele. (J:50528)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Scnn1g Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:50528
Barker PM et al.,
"Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism."
J Clin Invest 1998 Oct 15;102(8):1634-40
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All: |
1 reference(s)
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Analysis Tools
