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| Nomenclature |
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Symbol:
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Blmtm4Ches
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Name:
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Bloom syndrome, RecQ helicase-like;
targeted mutation 4, Nicholas Chester
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MGI ID: |
MGI:3663359 |
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Synonyms: |
Blmflox |
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Gene:
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Blm
Location:
Chr7:80454993-80535119 bp, - strand
Genetic Position: Chr7,
45.65 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:112115
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed PGK-neomycin resistance gene was inserted into intron 8 and an additional loxP site was placed in intron 7, 75 bp from the start of exon 8. Transient cre expression removed the PGK-neo sequence from correctly targeted ES cells, leaving loxP sites flanking exon 8. (J:112115)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:112115
Chester N et al.,
"Mutation of the murine Bloom's syndrome gene produces global genome destabilization."
Mol Cell Biol 2006 Sep;26(17):6713-26
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All: |
5 reference(s)
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Analysis Tools
