|
|
| Nomenclature |
|
Symbol:
|
Clic5jbg
|
|
Name:
|
chloride intracellular channel 5;
jitterbug
|
|
MGI ID: |
MGI:3663254 |
|
Gene:
|
Clic5
Location:
Chr17:44188572-44280168 bp, + strand
Genetic Position: Chr17,
20.53 cM, cytoband C
|
|
Mutation
origin |
|
Strain of Origin:
|
C3H/HeJ
|
|
Mutation
description |
|
Allele
Type: | |
Spontaneous |
|
Mutation: | |
Intragenic deletion |
| |
|
Mutation details: A 97 base pair deletion, including the 3'-most 87 base pairs of exon 5 and 10 base pairs of the flanking intron sequence including the exon/intron splice donor recognition sequence, results in a frame shift and premature stop codon in both Clic5A and Clic5B transcripts, effectively resulting in a null mutation of both transcripts. (J:112741)
|
|
Inheritance: | |
Recessive |
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:112741
Gagnon LH et al.,
"The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function."
J Neurosci 2006 Oct 4;26(40):10188-98
|
|
All: |
3 reference(s)
|
|
Analysis Tools
