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| Nomenclature |
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Symbol:
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Tg(Ins2-Fas*I246N)1Ach
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Name:
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transgene insertion 1, Alexander V Chervonsky
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MGI ID: |
MGI:3662920 |
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Synonyms: |
RIP-Fascg, RIP-Fascg Tg-Hi, RIP-Fas-lprcg, Tg(Ins2-Tnfrsf6lpr-cg) |
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Transgene:
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Tg(Ins2-Fas*I246N)1Ach
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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NOD/ShiLt
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Fas cDNA with a single nucleotide change leading to a I246N change in protein sequence, which codes for Fascg was subcloned into the rat insulin 2 promoter and injected into NOD/Lt oocytes to produce transgenic mice. (J:81416)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:81416
Savinov AY et al.,
"Contribution of Fas to diabetes development."
Proc Natl Acad Sci U S A 2003 Jan 21;100(2):628-32
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All: |
1 reference(s)
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Analysis Tools
