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| Nomenclature |
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Symbol:
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Mkl1tm1Eno
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Name:
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MKL (megakaryoblastic leukemia)/myocardin-like 1;
targeted mutation 1, Eric N Olson
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MGI ID: |
MGI:3662669 |
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Gene:
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Mkl1
Location:
Chr15:81012281-81190757 bp, - strand
Genetic Position: Chr15,
37.98 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:111412
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A vector was designed to delete a part of exon 9 and all of exon 10, which encode the basic, glutamine-rich and SAP domains. A lacZ was fused in frame with exon 9 and a neo cassette. RT-PCR demonstrated that the correct exons were deleted and that exon 8 was spliced to exon 12, thereby deleting the lacZ-neo cassette. The resulting truncated protein would be nonfunctional. (J:111412)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mkl1 Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:111412
Li S et al.,
"Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells."
Mol Cell Biol 2006 Aug;26(15):5797-808
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All: |
6 reference(s)
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Analysis Tools
