|
|
| Nomenclature |
|
Symbol:
|
Xrcc2tm1Pmc
|
|
Name:
|
X-ray repair complementing defective repair in Chinese hamster cells 2;
targeted mutation 1, Peter J McKinnon
|
|
MGI ID: |
MGI:3654106 |
|
Synonyms: |
Xrcc2- |
|
Gene:
|
Xrcc2
Location:
Chr5:25689812-25705825 bp, - strand
Genetic Position: Chr5,
12.35 cM, cytoband A3
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:111068
|
|
Parent Cell Line:
| W9.5/W95 (ES Cell) |
|
Strain of Origin:
|
129S1/Sv-Oca2+ Tyr+ Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A floxed neo cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 (75% of the open reading frame). RT-PCR failed to detect transcript in mutant mouse embryonic fibroblasts. (J:111068)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
This allele was generated from Xrcc2tm2Pmc.
|
| References |
|
Original: |
J:111068
Orii KE et al.,
"Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development."
Proc Natl Acad Sci U S A 2006 Jun 27;103(26):10017-22
|
|
All: |
1 reference(s)
|
|
Analysis Tools
