|
|
| Nomenclature |
|
Symbol:
|
Ryr2tm1Sgp
|
|
Name:
|
ryanodine receptor 2, cardiac;
targeted mutation 1, Silvia G Priori
|
|
MGI ID: |
MGI:3641338 |
|
Synonyms: |
Ryr2R4496C |
|
Gene:
|
Ryr2
Location:
Chr13:11553103-12106945 bp, - strand
Genetic Position: Chr13,
4.38 cM, cytoband A1-A2
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:109683
|
|
Parent Cell Line:
| Other (see notes) (ES Cell) |
|
Strain of Origin:
|
129/Sv
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A targeting vector was used to introduce an R4496C mutation into exon 94 of the locus. LoxP sites were inserted to flank the exon. (J:109683)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Ryr2 Mutation:
|
31 strains or lines available |
|
|
Notes |
ES cell line = TVB2.
|
| References |
|
Original: |
J:109683
Cerrone M et al.,
"Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor."
Circ Res 2005 May 27;96(10):e77-82
|
|
All: |
9 reference(s)
|
|
Analysis Tools
