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| Nomenclature |
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Symbol:
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Sh2d1b1tm1Vei
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Name:
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SH2 domain protein 1B1;
targeted mutation 1, Andre Veillette
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MGI ID: |
MGI:3641174 |
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Synonyms: |
EAT-2-deficient, Sh2d1b-/- |
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Gene:
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Sh2d1b1
Location:
Chr1:170277376-170285662 bp, + strand
Genetic Position: Chr1,
76.84 cM, cytoband H2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:110195
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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A targeting construct disrupted exon 2 of the gene creating a null allele. (J:110195)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sh2d1b1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:110195
Roncagalli R et al.,
"Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor."
Nat Immunol 2005 Oct;6(10):1002-10
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All: |
1 reference(s)
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Analysis Tools
