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| Nomenclature |
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Symbol:
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Dicer1tm1Smr
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Name:
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dicer 1, ribonuclease type III;
targeted mutation 1, Sarah E Millar
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MGI ID: |
MGI:3641051 |
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Synonyms: |
DicerflEx22-23, Dicerflox |
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Gene:
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Dicer1
Location:
Chr12:104687742-104751952 bp, - strand
Genetic Position: Chr12,
54.83 cM, cytoband E-F1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:110268
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed Dicer1 allele was created in a stem cell line (4E4) which contained a null Dicer1 allele, Dicer1tm1Ghan. A Dicer1 allele with exons 22 and 23 flanked by loxP sites replaced the remaining wild-type Dicer1 allele in the ES cells. The resulting ES cells were used to create conditional mice homozygous for the floxed Dicer1 allele. (J:101186)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:110268
Andl T et al.,
"The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles."
Curr Biol 2006 May 23;16(10):1041-9
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All: |
25 reference(s)
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Analysis Tools
