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| Nomenclature |
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Symbol:
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Gnmttm1Cwa
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Name:
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glycine N-methyltransferase;
targeted mutation 1, Conrad Wagner
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MGI ID: |
MGI:3640328 |
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Gene:
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Gnmt
Location:
Chr17:46725664-46729168 bp, - strand
Genetic Position: Chr17,
22.9 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:110257
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The first exon and promoter region were replaced with a neomycin resistance gene via homologous recombination. Western blot and enzyme activity assays did not detect any protein or activity in homozygous liver extracts. (J:110257)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:110257
Luka Z et al.,
"A Glycine N-methyltransferase Knockout Mouse Model for Humans with Deficiency of this Enzyme."
Transgenic Res 2006 Jun;15(3):393-7
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All: |
3 reference(s)
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Analysis Tools
