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| Nomenclature |
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Symbol:
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Cd4tm1Jrp
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Name:
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CD4 antigen;
targeted mutation 1, Jane R Parnes
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MGI ID: |
MGI:3639344 |
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Synonyms: |
Cd4low |
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Gene:
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Cd4
Location:
Chr6:124864692-124888221 bp, - strand
Genetic Position: Chr6,
59.17 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:45168
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 10, 3' to the coding sequences of the gene. This allele expresses a twofold lower level of the encoded protein in the thymus and thus behaves as a hypomorph. (J:45168)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cd4 Mutation:
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42 strains or lines available |
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| References |
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Original: |
J:45168
Frank GD et al.,
"The level of CD4 surface protein influences T cell selection in the thymus."
J Immunol 1998 Jan 15;160(2):634-42
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All: |
1 reference(s)
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Analysis Tools
