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| Nomenclature |
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Symbol:
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Terttm1Rdp
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Name:
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telomerase reverse transcriptase;
targeted mutation 1, Ronald DePinho
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MGI ID: |
MGI:3628579 |
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Synonyms: |
mTert1- |
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Gene:
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Tert
Location:
Chr13:73627001-73649041 bp, + strand
Genetic Position: Chr13,
40.12 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:108914
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Exon 1, containing the ATG and encoding the RNA/DNA binding domain, was deleted. Activity of the mutant protein was not detected in the TRAP assay. (J:108914)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tert Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:108914
Farazi PA et al.,
"Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression."
Cancer Res 2006 May 1;66(9):4766-73
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All: |
3 reference(s)
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Analysis Tools
