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| Nomenclature |
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Symbol:
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Artm3(AR)Dmr
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Name:
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androgen receptor;
targeted mutation 3, Diane M Robins
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MGI ID: |
MGI:3628492 |
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Synonyms: |
48Q, AR48Q, Artm3Apl |
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Gene:
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Ar
Location:
ChrX:98149721-98323215 bp, + strand
Genetic Position: ChrX,
42.82 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:108849
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: Human androgen receptor amino acids 31 to 484 were inserted into the mouse locus. This allele contains 48 glutamine residues in the N terminal. Transient cre expression removed a floxed neo from the recombined locus. RT-PCR demonstrated higher levels of transcript in mutants than wild-type. Western blot showed that protein levels were also somewhat higher. (J:108849)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:108849
Albertelli MA et al.,
"Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice."
Mol Endocrinol 2006 Jun;20(6):1248-60
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All: |
6 reference(s)
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Analysis Tools
