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| Nomenclature |
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Symbol:
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Tg(Afp-IGFBP1)2Csw
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Name:
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transgene insertion 2, Carole Watson
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MGI ID: |
MGI:3624007 |
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Transgene:
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Tg(Afp-IGFBP1)2Csw
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A 9.2kb transgene containing the human IGFBP1 cDNA under the control of the mouse alpha-fetoprotein regulatory sequence was microinjected into the pronuclei of C57BL/6 x CBA F1 embryos. Four founder lines were established (2,3,4,16). Line 2 contains 4 copies of the transgene and expresses at high levels in fetal liver and yolk sac with lower levels of expression in gut epithelial cells and brain glial cells. (J:108414)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:108414
Watson CS et al.,
"Elevated circulating insulin-like growth factor binding protein-1 is sufficient to cause fetal growth restriction."
Endocrinology 2006 Mar;147(3):1175-86
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All: |
1 reference(s)
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Analysis Tools
