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| Nomenclature |
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Symbol:
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Jag1tm1Jlew
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Name:
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jagged 1;
targeted mutation 1, Julian Lewis
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MGI ID: |
MGI:3623344 |
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Synonyms: |
Jag1flox |
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Gene:
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Jag1
Location:
Chr2:137081456-137116644 bp, - strand
Genetic Position: Chr2,
67.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:107414
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites were inserted to flank exons encoding the DSL (Delta-Serrate-Lag2) domain required for binding to Notch. Expression of cre recombinase is expected to knock out gene function by removing exons 4 and 5 (the DSL encoding exons) and causing a frame shift that generates a stop codon after the start of exon 6. (J:107414)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Jag1 Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:107414
Brooker R et al.,
"Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear."
Development 2006 Apr;133(7):1277-86
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All: |
11 reference(s)
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Analysis Tools
