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| Nomenclature |
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Symbol:
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Cln3tm1Mkat
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Name:
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ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease);
targeted mutation 1, Martin L Katz
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MGI ID: |
MGI:3623134 |
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Gene:
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Cln3
Location:
Chr7:126571207-126585817 bp, - strand
Genetic Position: Chr7,
69.16 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:57155
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced most of exon 7 and all of exon 8. No complete transcript was detected in mutants, however, two smaller mRNA transcripts putatively resulting from alternative splicing around the neo were detected. (J:57155)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:57155
Katz ML et al.,
"A mouse gene knockout model for juvenile ceroid-lipofuscinosis (Batten disease)."
J Neurosci Res 1999 Aug 15;57(4):551-6
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All: |
2 reference(s)
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Analysis Tools
