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| Nomenclature |
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Symbol:
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Hprttm1(Pck1-cre)Vhh
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Name:
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hypoxanthine guanine phosphoribosyl transferase;
targeted mutation 1, Volker H Haase
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MGI ID: |
MGI:3621174 |
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Synonyms: |
PEPCK-Cre |
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Gene:
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Hprt
Location:
ChrX:52988137-53021659 bp, + strand
Genetic Position: ChrX,
29.31 cM, cytoband A6
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:106705
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: The rat phosphoenolpyruvate carboxykinase 1, cytosolic promoter was used to drive expression of cre recombinase in the renal proximal tubule. The promoter was mutated in such a way that expression in the liver was reduced by 60% and increased in the kidney by 10-fold in mutant mice. The construct was inserted into ES cells lacking Hprt. (J:106705)
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Recombinase activity
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Driver:
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Pck1
Summary of all recombinase alleles
driven by Pck1.
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MGI has not yet included tissue activity data for this allele in any anatomical systems.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:106705
Rankin EB et al.,
"Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor."
Cancer Res 2006 Mar 1;66(5):2576-83
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All: |
12 reference(s)
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Analysis Tools
