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| Nomenclature |
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Symbol:
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Tg(IGL-MYC)3Hm
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Name:
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transgene insertion 3, Herbert Morse
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MGI ID: |
MGI:3619458 |
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Synonyms: |
lambda-hu-MYC, lambda-MYC |
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Transgene:
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Tg(IGL-MYC)3Hm
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6N
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A mutant human MYC gene isolated from a Burkitt lymphoma cell line and characterized by a shift in promoter use from P2 to P1 is fused to a 12 kb human genomic DNA segment containing the intronic enhancer and other functional elements of the IGL locus control region. RT-PCR analysis of various tissues of young, lymphoma-free transgenic mice detects high levels of MYC mRNA in lymphoid tissues, but no or very low levels elsewhere. Immunoblot analysis with human MYC-specific antibodies consistently detects low levels of the protein in spleens of transgenic mice. (J:65245)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:65245
Kovalchuk AL et al.,
"Burkitt lymphoma in the mouse"
J Exp Med 2000 Oct 16;192(8):1183-90
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All: |
11 reference(s)
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Analysis Tools
