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| Nomenclature |
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Symbol:
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Rb1tm1Dwg
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Name:
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retinoblastoma 1;
targeted mutation 1, David W Goodrich
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MGI ID: |
MGI:3617652 |
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Synonyms: |
Rb1654, Rb R654W |
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Gene:
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Rb1
Location:
Chr14:73183673-73325822 bp, - strand
Genetic Position: Chr14,
38.73 cM, cytoband D3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:105548
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed to insert a R654W substitution into exon 20. A floxed neo in intron 19 was removed via cre mediated recombination. Western blot demonstrated protein levels were approximately the same in mutants and wild-type. (J:105548)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rb1 Mutation:
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32 strains or lines available |
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| References |
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Original: |
J:105548
Sun H et al.,
"An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity."
Mol Cell Biol 2006 Feb;26(4):1527-37
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All: |
3 reference(s)
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Analysis Tools
