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| Nomenclature |
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Symbol:
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Sostdc1tm1Myan
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Name:
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sclerostin domain containing 1;
targeted mutation 1, Motoko Yanagita
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MGI ID: |
MGI:3617495 |
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Synonyms: |
USAG1- |
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Gene:
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Sostdc1
Location:
Chr12:36314169-36318452 bp, + strand
Genetic Position: Chr12,
16.82 cM, cytoband B2
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Sostdc1tm1Myan/Sostdc1tm1Myan Col4a3tm1Dec/Col4a3tm1Dec mice show less glomerular and tubular injury than Col4a3tm1Dec/Col4a3tm1Dec mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:105264
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 was disrupted by the insertion of a nuclear lacZ gene and neo cassette. The transcription initiation codon, signal peptide and the following 46 amino acids were removed. Northern blot analysis failed to detect transcript in kidney samples from homozygous mutants. (J:105264)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sostdc1 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:105264
Yanagita M et al.,
"Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury."
J Clin Invest 2006 Jan;116(1):70-9
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All: |
4 reference(s)
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Analysis Tools
