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| Nomenclature |
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Symbol:
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Tuba1aJna
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Name:
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tubulin, alpha 1A;
jenna
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MGI ID: |
MGI:3617352 |
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Gene:
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Tuba1a
Location:
Chr15:98949841-98953551 bp, - strand
Genetic Position: Chr15,
55.29 cM
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Mutation
origin |
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Strain of Origin:
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BALB/cAnN
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: This phenotypic mutation was identified in an ENU mutagenesis screen and contains a mutation that causes an amino acid change from serine to glycine at residue 140. This mutation reduced GTP binding and native heterodimer formation. (J:117881)
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Inheritance: | |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:117881
Keays DA et al.,
"Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans."
Cell 2007 Jan 12;128(1):45-57
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All: |
3 reference(s)
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Analysis Tools
