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| Nomenclature |
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Symbol:
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Pkd1tm2.1Ggg
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Name:
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polycystic kidney disease 1 homolog;
targeted mutation 2.1, Gregory G Germino
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MGI ID: |
MGI:3617325 |
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Synonyms: |
Pkd1del2-4 |
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Gene:
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Pkd1
Location:
Chr17:24549950-24596514 bp, + strand
Genetic Position: Chr17,
12.4 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:103719
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: This allele was generated by breeding mice carrying Pkd1tm2Ggg with Meox2tm1(cre)Sor mice that express cre in the germline. Cre-mediated recombination removed exons 2 to 4. RT-PCR shows that mutant transcripts lack exons 2-4. (J:103719)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pkd1 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:103719
Piontek KB et al.,
"A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo."
J Am Soc Nephrol 2004 Dec;15(12):3035-43
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All: |
5 reference(s)
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Analysis Tools
