Tg(Atoh1-cre/Esr1*)14Fsh
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Atoh1-cre/Esr1*)14Fsh
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Name:
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transgene insertion 14, Gordon Fishell
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MGI ID: |
MGI:3615691 |
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Synonyms: |
Atoh1-cre, Math1-cre, Math1-CreERT2, Tg(Atoh1-cre/ESR1)1Fsh, Tg(HBB-cre)1Fsh |
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Transgene:
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Tg(Atoh1-cre/Esr1*)14Fsh
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: The transgene was designed with a 1.4 kb mouse Math1 (Atoh1) 3' enhancer (and a beta-globin minimal promoter) sequence upstream of a CreERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Tamoxifen-inducible cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordia (with a limited amount of ectopic expression in the primordium of the hippocampus but not the cortex). (J:105186)
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Recombinase activity
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Activity in:
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nervous system,
sensory organs
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Not detected in:
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adipose tissue,
alimentary system,
cardiovascular system,
endocrine system,
hemolymphoid system,
integumental system,
liver & biliary system,
renal & urinary system,
reproductive system,
respiratory system
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Driver:
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Atoh1
Summary of all recombinase alleles
driven by Atoh1.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:105186
Machold R et al.,
"Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors."
Neuron 2005 Oct 6;48(1):17-24
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All: |
20 reference(s)
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Analysis Tools
