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| Nomenclature |
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Symbol:
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Polktm1Hohm
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Name:
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polymerase (DNA directed), kappa;
targeted mutation 1, Haruo Ohmori
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MGI ID: |
MGI:3615272 |
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Synonyms: |
Polk-, Polktm1Taz |
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Gene:
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Polk
Location:
Chr13:96480689-96542485 bp, - strand
Genetic Position: Chr13,
50.56 cM, cytoband D1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:83202
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A targeting vector was designed to replace exon 5 with a PGK-neo cassette. Mutant ES cells failed to express protein. (J:91863)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Polk Mutation:
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19 strains or lines available |
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Notes |
Homozygous ES cells grow normally, however they slightly more sensitive to UV and x-ray radiation and are hypersensitive to both killing and mutagenesis induced by benzo[a]pyrene (B[a]P) (J:91863).
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| References |
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Original: |
J:83202
Shimizu T et al.,
"The absence of DNA polymerase kappa does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene."
Immunol Lett 2003 May 1;86(3):265-70
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All: |
3 reference(s)
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Analysis Tools
