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| Nomenclature |
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Symbol:
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Pmp22tm1Lnot
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Name:
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peripheral myelin protein 22;
targeted mutation 1, Lucia Notterpek
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MGI ID: |
MGI:3614822 |
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Gene:
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Pmp22
Location:
Chr11:63128982-63159547 bp, + strand
Genetic Position: Chr11,
38.99 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:104989
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: Velocigene technology was used to insert a cassette containing a lacZ-stop-PGK-noe-stop cassette immediately downstream of the ATG in exon 2, subsequently replacing the rest of exon 2 and all of exon 3. Western blot did not detect protein in mutant sciatic nerve lysates. Beta-gal expression was detected widely in the E15 mouse embryo. (J:104989)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pmp22 Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:104989
Amici SA et al.,
"Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina."
J Neurosci 2006 Jan 25;26(4):1179-89
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All: |
1 reference(s)
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Analysis Tools
