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| Nomenclature |
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Symbol:
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Tg(APOA1)427Bres
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Name:
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transgene insertion 427, Jan L Breslow
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MGI ID: |
MGI:3614555 |
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Synonyms: |
hA-ITg, Tg(OHSA-AI)427 |
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Transgene:
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Tg(APOA1)427Bres
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x CBA/J)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene construct was composed of a 2.2 kb genomic clone of the human gene and contained 256 bp of 5' sequence. Ten to 50 copies were inserted. The human gene is expressed in liver but not in intestine, testis, or ovary. Average human APOA-I levels are 339mg/dl. (J:94253)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:94253
Walsh A et al.,
"High levels of human apolipoprotein A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3."
J Biol Chem 1989 Apr 15;264(11):6488-94
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All: |
12 reference(s)
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Analysis Tools
