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| Nomenclature |
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Symbol:
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F10tm1Edr
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Name:
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coagulation factor X;
targeted mutation 1, Elliot D Rosen
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MGI ID: |
MGI:3613747 |
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Synonyms: |
FX- |
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Gene:
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F10
Location:
Chr8:13037308-13056676 bp, + strand
Genetic Position: Chr8,
5.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:61230
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced 18kb of sequence including exons 2-8, which encode the mature protein. RT-PCR analysis did not detect transcript in liver from homozygous E17.5 mutant embryos. Immunohistochemical analysis did not detect protein in liver sections from homozygous E17.5 mutant embryos. (J:61230)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any F10 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:61230
Dewerchin M et al.,
"Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice"
Thromb Haemost 2000 Feb;83(2):185-90
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All: |
1 reference(s)
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Analysis Tools
