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| Nomenclature |
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Symbol:
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Tg(YAC128)53Hay
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Name:
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transgene insertion 53, Michael Hayden
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MGI ID: |
MGI:3613515 |
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Synonyms: |
HD53, YAC128, YAC 128 |
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Transgene:
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Tg(YAC128)53Hay
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A YAC containing a full-length human huntingtin gene under the control of the endogenous human HDH promoter was modified with a 128 CAG repeat expansion. The resulting construct (YAC128) was used to generate transgenic mice. Founder line 53 integrated the most copies of the transgene and had the highest levels of protein expression (75% of endogenous levels) as determined by densitometric analysis. (J:84453)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:84453
Slow EJ et al.,
"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease."
Hum Mol Genet 2003 Jul 1;12(13):1555-67
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All: |
20 reference(s)
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Analysis Tools
