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| Nomenclature |
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Symbol:
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Ccr2tm1Blck
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Name:
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chemokine (C-C motif) receptor 2;
targeted mutation 1, Bruno Luckow
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MGI ID: |
MGI:3613374 |
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Synonyms: |
Ccr2-, Ccr2tm1Dscg |
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Gene:
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Ccr2
Location:
Chr9:124101950-124113557 bp, + strand
Genetic Position: Chr9,
75.05 cM, cytoband F
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:113343
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Most of the open reading frame is replaced by an EGFP reporter gene and a floxed neomycin resistance cassette. Absence of protein on the cell surface was demonstrated by flow cytometry. (J:113343)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ccr2 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:113343
de Lema GP et al.,
"Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice."
J Am Soc Nephrol 2005 Dec;16(12):3592-601
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All: |
3 reference(s)
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Analysis Tools
