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| Nomenclature |
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Symbol:
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Abca1tm2Jp
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Name:
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ATP-binding cassette, sub-family A (ABC1), member 1;
targeted mutation 2, John S Parks
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MGI ID: |
MGI:3613250 |
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Synonyms: |
Abca1- |
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Gene:
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Abca1
Location:
Chr4:53030787-53159895 bp, - strand
Genetic Position: Chr4,
28.57 cM, cytoband A5-B3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:104719
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Parent Cell Line:
| ESVJ (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene replaced exons 17-22 of the locus, which encode the first nucleotide binding domain. (J:104719)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:104719
Lee JY et al.,
"HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney."
J Lipid Res 2005 Oct;46(10):2233-45
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All: |
4 reference(s)
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Analysis Tools
