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| Nomenclature |
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Symbol:
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Wfs1tm1Perm
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Name:
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Wolfram syndrome 1 homolog (human);
targeted mutation 1, M A Permutt
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MGI ID: |
MGI:3613056 |
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Gene:
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Wfs1
Location:
Chr5:36966104-36988982 bp, - strand
Genetic Position: Chr5,
19.46 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:104712
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites were inserted to flank exon 8, which encodes the transmembrane domain and two-thirds of the protein. (J:104712)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Wfs1 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:104712
Riggs AC et al.,
"Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis."
Diabetologia 2005 Nov;48(11):2313-21
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All: |
1 reference(s)
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Analysis Tools
