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| Nomenclature |
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Symbol:
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Tg(Gria2*586N)238.2Rsp
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Name:
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transgene insertion 238.2, Rolf Sprengel
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MGI ID: |
MGI:3612450 |
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Synonyms: |
GluR-B(N), GluR-BNtrans |
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Transgene:
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Tg(Gria2*586N)238.2Rsp
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene contains multiple copies of a Gria2(N) minigene which encodes an asparagine (N) at the Q/R site. Specifically, the minigene is constructed from a 6 kb genomic DNA fragment comprising over 5 kb of the upstream region, including the Gria2 promoter, exon 1 and part of intron 1, a 1.1-kb KpnI fragment, itself the fusion of two PCR products connecting the murine intron 1 sequence to rat Gria2 cDNA, plus a fragment of Gria2 flip cDNA, mutated to contain an asparagine (N) codon for the Q/R site. Several lines were made with line L238.2 showing highest expression. (J:51845)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:51845
Feldmeyer D et al.,
"Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B."
Nat Neurosci 1999 Jan;2(1):57-64
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All: |
2 reference(s)
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Analysis Tools
