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| Nomenclature |
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Symbol:
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Btktm1Witt
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Name:
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Bruton agammaglobulinemia tyrosine kinase;
targeted mutation 1, Owen N Witte
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MGI ID: |
MGI:3612416 |
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Synonyms: |
Btk Y375F |
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Gene:
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Btk
Location:
ChrX:134542336-134583570 bp, - strand
Genetic Position: ChrX,
56.18 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:104167
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed to insert a Y375F mutation into exon 13. Mutant mice showed normal B cell development and function. (J:104167)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Btk Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:104167
Guo S et al.,
"Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families."
Int Immunol 2006 Jan;18(1):79-87
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All: |
1 reference(s)
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Analysis Tools
