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| Nomenclature |
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Symbol:
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Pax9tm1Hpt
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Name:
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paired box gene 9;
targeted mutation 1, Heiko Peters
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MGI ID: |
MGI:3612401 |
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Synonyms: |
Pax9neo |
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Gene:
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Pax9
Location:
Chr12:56691767-56712822 bp, + strand
Genetic Position: Chr12,
24.53 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:104121
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Parent Cell Line:
| TBV2 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: An FRT-flanked neomycin resistance cassette was inserted into intron 2. loxP sites were inserted to flank exons 1 and 2. RT-PCR and sequencing revealed the presence of alternatively spliced forms resulting from the splicing of paired box-containing exon 2 to the 3' region of the Pgk1 promoter. With the neo coding region in frame with exon 2 of Pax9, translation of the mRNA predicts and aberrant fusion protein containing the paired domain and the full-length neomycin phosphotransferase, but lacking most of the C-terminal of Pax9. (J:104121)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pax9 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:104121
Kist R et al.,
"Reduction of Pax9 gene dosage in an allelic series of mouse mutants causes hypodontia and oligodontia."
Hum Mol Genet 2005 Dec 1;14(23):3605-17
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All: |
2 reference(s)
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Analysis Tools
