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| Nomenclature |
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Symbol:
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Pkd1tm2Ggg
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Name:
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polycystic kidney disease 1 homolog;
targeted mutation 2, Gregory G Germino
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MGI ID: |
MGI:3612341 |
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Synonyms: |
Pkd1cond |
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Gene:
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Pkd1
Location:
Chr17:24549950-24596514 bp, + strand
Genetic Position: Chr17,
12.4 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:103719
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin cassette flanked by FRT sites and a single loxP site at the 3' end was inserted into intron 1. Another loxP site was inserted into intron 4 in the same orientation such that exons 2-4 could be removed upon expression of cre recombinase. (J:103719)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:103719
Piontek KB et al.,
"A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo."
J Am Soc Nephrol 2004 Dec;15(12):3035-43
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All: |
13 reference(s)
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Analysis Tools
