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| Nomenclature |
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Symbol:
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Pkd1tm1Ggg
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Name:
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polycystic kidney disease 1 homolog;
targeted mutation 1, Gregory G Germino
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MGI ID: |
MGI:3612339 |
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Synonyms: |
Pkd1-, Pkd1Beta-gal null, Pkd1Betagal-null |
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Gene:
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Pkd1
Location:
Chr17:24549950-24596514 bp, + strand
Genetic Position: Chr17,
12.4 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76062
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Most of exon 2 and all of exon 3 were replaced with lacZ gene in frame to the 5' end of exon 2. This is a true null allele because of transcription termination after the beta-galactosidase gene. lacZ expression is driven by the endogenous promoter. (J:76062, J:103719)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pkd1 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:76062
Bhunia AK et al.,
"PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2."
Cell 2002 Apr 19;109(2):157-68
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All: |
9 reference(s)
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Analysis Tools
