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| Nomenclature |
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Symbol:
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Kcnk3tm1Sgb
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Name:
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potassium channel, subfamily K, member 3;
targeted mutation 1, Stephen G Brinkley
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MGI ID: |
MGI:3611768 |
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Synonyms: |
TASK-1 - |
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Gene:
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Kcnk3
Location:
Chr5:30588170-30625270 bp, + strand
Genetic Position: Chr5,
16.68 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:103747
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1, encoding the first transmembrane domain through the beginning of the first P1 loop was disrupted by homologous recombination. An IRES-lacZ-SV40pA-neo cassette containing a stop codon in all three reading frames replaced the first 21 amino acids. In situ hybridization and real time PCR showed that the targeted allele is not expressed in either mutant brain or heart samples. (J:103747)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Kcnk3 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:103747
Aller MI et al.,
"Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons."
J Neurosci 2005 Dec 7;25(49):11455-67
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All: |
10 reference(s)
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Analysis Tools
