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| Nomenclature |
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Symbol:
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Abcb1btm1Bor
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Name:
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ATP-binding cassette, sub-family B (MDR/TAP), member 1B;
targeted mutation 1, Piet Borst
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MGI ID: |
MGI:3610191 |
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Synonyms: |
mdr1a/1b-, Mdr1a/b- |
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Gene:
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Abcb1b
Location:
Chr5:8798147-8866314 bp, + strand
Genetic Position: Chr5,
3.43 cM, cytoband A2-A3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:39804
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: ES cells containing a previously targeted Abcb1a allele (Abcb1atm1Bor) were targeted again with a vector replacing exons 3 and 4 of Abcb1b with a neomycin selection cassette. The vector contained a MluI linker 3' of the neo cassette that allowed detection of the Abcb1b disruption linked to the previous Abcb1a disruption by long-range restriction mapping. (J:39804)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Abcb1b Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:39804
Schinkel AH et al.,
"Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins."
Proc Natl Acad Sci U S A 1997 Apr 15;94(8):4028-33
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All: |
53 reference(s)
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Analysis Tools
