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| Nomenclature |
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Symbol:
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Sgcgtm1Oza
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Name:
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sarcoglycan, gamma (dystrophin-associated glycoprotein);
targeted mutation 1, Eijiro Ozawa
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MGI ID: |
MGI:3609567 |
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Synonyms: |
gsg- |
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Gene:
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Sgcg
Location:
Chr14:61221059-61258490 bp, - strand
Genetic Position: Chr14,
32.27 cM, cytoband C3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:102780
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene replaced exon 3, which encodes the translation initiation site, the cytoplasmic domain, and the transmembrane domain of the encoded protein. Immunoblot analysis detected markedly reduced expression of alpha, beta and delta subunits and complete lack of the gamma subunit. (J:102780)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:102780
Sasaoka T et al.,
"Pathological analysis of muscle hypertrophy and degeneration in muscular dystrophy in gamma-sarcoglycan-deficient mice."
Neuromuscul Disord 2003 Mar;13(3):193-206
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All: |
2 reference(s)
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Analysis Tools
